巨噬细胞在淋巴细胞对黏性放线菌反应中的作用。
Role of macrophages in the lymphocyte response to Actinomyces viscosus.
作者信息
McCarron R M, Fitzgerald J E, Birdsell D C
出版信息
Infect Immun. 1982 Nov;38(2):623-30. doi: 10.1128/iai.38.2.623-630.1982.
Macrophage cooperation has been considered necessary for lymphocytes to express a variety of their differentiated functions. We attempted to characterize macrophage-lymphocyte cooperation in response to a known periodontal pathogen. Actinomyces viscosus T14V. Using adherent murine cells and subpopulations of splenocyte cultures, we assessed the effect of A. viscosus T14V fractions on lymphocyte proliferation. We determined that (i) various fractions of A. viscosus induced different proliferative responses; (ii) the physical state of the A. viscosus component determined the degree of dependence on adherent cells for proliferation; (iii) the proliferative response to supernatants of sonicated A. viscosus involved interaction among adherent cells and T and B cells; and (iv) the effects of adherent cells on the proliferative response were due to cell-to-cell interactions.
巨噬细胞的协同作用被认为是淋巴细胞表达其多种分化功能所必需的。我们试图描述巨噬细胞与淋巴细胞针对一种已知的牙周病原体——粘性放线菌T14V的协同作用。利用贴壁小鼠细胞和脾细胞培养亚群，我们评估了粘性放线菌T14V组分对淋巴细胞增殖的影响。我们确定：（i）粘性放线菌的不同组分诱导不同的增殖反应；（ii）粘性放线菌组分的物理状态决定了增殖对贴壁细胞的依赖程度；（iii）对超声处理的粘性放线菌上清液的增殖反应涉及贴壁细胞与T细胞和B细胞之间的相互作用；（iv）贴壁细胞对增殖反应的影响归因于细胞间相互作用。
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