Prowse S J
Parasite Immunol. 1982 Sep;4(5):363-72. doi: 10.1111/j.1365-3024.1982.tb00448.x.
The lymphokine Interleukin 2 (IL2) is secreted by T lymphocytes from mice infected by the murine parasitic nematode Nematospiroides dubius upon in vitro re-stimulation by specific parasite antigens. This study showed that the lymphocytes secreting IL2 were located in the lymphoid tissues draining the site of infection as well as in the spleen and peritoneal cavity of infected mice. There were marked fluctuations in the numbers of IL2 secreting cells in the posterior gastric lymph nodes and the peritoneal cavity at various times following single or multiple infections. However, there was no correlation between the appearance of IL2 secreting cells in infected mice and the development of resistance to re-infection by third stage larvae (L3). The specificity of the IL2 response for N. dubius antigens was demonstrated by the finding that antigen preparations from other helminths did not stimulate a response. It was also found that living but not killed N. dubius L3 could stimulate IL2 secretion, emphasizing the importance of living L3 in the induction of resistance to re-infection.
淋巴因子白细胞介素2（IL2）由感染鼠类寄生线虫杜氏嗜气管线虫的小鼠的T淋巴细胞在受到特定寄生虫抗原的体外再刺激后分泌。本研究表明，分泌IL2的淋巴细胞位于感染部位引流的淋巴组织以及感染小鼠的脾脏和腹腔中。在单次或多次感染后的不同时间，后胃淋巴结和腹腔中分泌IL2的细胞数量有明显波动。然而，感染小鼠中分泌IL2的细胞的出现与对三期幼虫（L3）再次感染的抵抗力的发展之间没有相关性。来自其他蠕虫的抗原制剂不能刺激反应，这一发现证明了IL2对杜氏嗜气管线虫抗原反应的特异性。还发现活的而非灭活的杜氏嗜气管线虫L3能刺激IL2分泌，强调了活的L3在诱导对再次感染的抵抗力中的重要性。
