• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种鼠类寄生线虫（杜氏新线虫）对补体的替代途径激活作用。

Alternative pathway activation of complement by a murine parasitic nematode (Nematospiroides dubius).

作者信息

Prowse S J, Ey P L, Jenkin C R

出版信息

Aust J Exp Biol Med Sci. 1979 Oct;57(5):459-66. doi: 10.1038/icb.1979.47.

DOI:10.1038/icb.1979.47
PMID:548018
Abstract

The cuticular surface of the infectious third-stage larvae of Nematospiroides dubius activates complement via the alternative pathway. Sensitisation of larvae with complement or with antibodies from the serum of immune mice (resistant to reinfection) promoted the adherence of mouse peritoneal exudate cells to the larval cuticle during incubation in vitro. The infectivity of larvae sensitized with antibody or complement was significantly reduced after incubation with cells from immune mice.

摘要

Dubius线虫感染性三期幼虫的角质表面通过替代途径激活补体。用补体或免疫小鼠（对再感染有抵抗力）血清中的抗体致敏幼虫，在体外孵育期间可促进小鼠腹腔渗出细胞与幼虫角质层的黏附。用抗体或补体致敏的幼虫与免疫小鼠的细胞孵育后，其感染力显著降低。

相似文献

1
Alternative pathway activation of complement by a murine parasitic nematode (Nematospiroides dubius).一种鼠类寄生线虫（杜氏新线虫）对补体的替代途径激活作用。
Aust J Exp Biol Med Sci. 1979 Oct;57(5):459-66. doi: 10.1038/icb.1979.47.
2
Adherence of murine peripheral blood eosinophils and neutrophils to the different parasitic stages of Nematospiroides dubius.小鼠外周血嗜酸性粒细胞和中性粒细胞对Dubius线虫不同寄生阶段的黏附情况。
Aust J Exp Biol Med Sci. 1983 Dec;61 ( Pt 6):617-27. doi: 10.1038/icb.1983.58.
3
Reduced infectivity of Nematospiroides dubius larvae after incubation in vitro with neutrophils or eosinophils from infected mice and a lack of effect by neutrophils from normal mice.将来自感染小鼠的嗜中性粒细胞或嗜酸性粒细胞与体外培养的Dubius线虫幼虫一起孵育后，其感染性降低，而正常小鼠的嗜中性粒细胞则无此作用。
Parasite Immunol. 1984 Jul;6(4):295-308. doi: 10.1111/j.1365-3024.1984.tb00802.x.
4
Studies in vitro on the reaction of peritoneal exudate cells from mice immune to infection with Nematospiroides dubius with the infective third stage larvae of this parasite.对感染双盘尾丝虫的免疫小鼠腹腔渗出细胞与该寄生虫感染性第三期幼虫反应的体外研究。
Aust J Exp Biol Med Sci. 1978 Feb;56(1):61-8. doi: 10.1038/icb.1978.7.
5
Cellular response and resistance to the primary infection of rats and mice with Nematospiroides dubius.大鼠和小鼠对 dubius 类圆线虫初次感染的细胞反应及抗性
Z Parasitenkd. 1982;68(3):339-47. doi: 10.1007/BF00927412.
6
The effect in vivo of peritoneal exudate cells of immune and normal mice on the infectivity of the third stage larvae of Nematospiroides dubius.免疫小鼠和正常小鼠的腹腔渗出细胞对Dubius旋毛虫第三期幼虫感染力的体内影响。
Aust J Exp Biol Med Sci. 1977 Oct;55(5):561-71. doi: 10.1038/icb.1977.55.
7
Interleukin 2 secretion by sensitized cells from mice infected with Nematospiroides dubius: kinetics and specificity of the response.感染Dubius线虫的小鼠致敏细胞分泌白细胞介素2：反应的动力学和特异性
Parasite Immunol. 1982 Sep;4(5):363-72. doi: 10.1111/j.1365-3024.1982.tb00448.x.
8
Passive transfer of immunity with serum in mice infected with Nematospiroides dubius: influence of quality and quantity of immune serum.用血清对感染杜氏丝状线虫的小鼠进行免疫的被动转移：免疫血清质量和数量的影响
Int J Parasitol. 1982 Jun;12(2-3):207-13. doi: 10.1016/0020-7519(82)90018-2.
9
Development of immunity in mice previously infected at an early age with Nematospiroides dubius.先前在幼年时感染了 dubius 旋毛虫的小鼠的免疫发育。
J Parasitol. 1973 Oct;59(5):776-9.
10
Non-specific immunodepression by larval and adult Nematospiroides dubius.
Parasitology. 1984 Feb;88 ( Pt 1):153-62. doi: 10.1017/s0031182000054421.

引用本文的文献

1
Antibody-mediated trapping of helminth larvae requires CD11b and Fcγ receptor I.抗体介导的蠕虫幼虫捕获需要CD11b和Fcγ受体I。
J Immunol. 2015 Feb 1;194(3):1154-63. doi: 10.4049/jimmunol.1401645. Epub 2014 Dec 29.
2
Loss of complement activation and leukocyte adherence as Nippostrongylus brasiliensis develops within the murine host.随着巴西日圆线虫在小鼠宿主体内发育，补体激活和白细胞黏附功能丧失。
Infect Immun. 2005 Nov;73(11):7442-9. doi: 10.1128/IAI.73.11.7442-7449.2005.
3
The innate allergenicity of helminth parasites.蠕虫寄生虫的先天性变应原性。
Clin Rev Allergy Immunol. 2004 Feb;26(1):61-72. doi: 10.1385/CRIAI:26:1:61.
4
Cellular response and resistance to the primary infection of rats and mice with Nematospiroides dubius.大鼠和小鼠对 dubius 类圆线虫初次感染的细胞反应及抗性
Z Parasitenkd. 1982;68(3):339-47. doi: 10.1007/BF00927412.