Prowse S J
Aust J Exp Biol Med Sci. 1981 Dec;59(Pt 6):695-705. doi: 10.1038/icb.1981.61.
The secretion of the lymphokine, Interleukin 2 (IL2), from cells obtained from the lymph nodes of mice infected by the murine nematode, Nematospiroides dubius, is used an indication of T cell recognition of parasite antigens. It is demonstrated that IL2 secretion is T cell-dependent and occurs only when the lymph node cells are cultivated in the presence of at least 5 micrograms/ml of a parasite antigen preparation. The presence of adherent peritoneal exudate cells from uninfected mice in the cultures is an essential requirement for lymphokine release. This system can be used to quantitate T cell recognition of parasite antigens and to study T cell/antigen-presenting-cell interactions involved in the immune response to parasite infection.
从小鼠线虫（Dubius线虫）感染的小鼠淋巴结获取的细胞中分泌的淋巴因子白细胞介素2（IL2），被用作T细胞对寄生虫抗原识别的指标。结果表明，IL2的分泌依赖于T细胞，并且只有当淋巴结细胞在至少5微克/毫升的寄生虫抗原制剂存在的情况下培养时才会发生。培养物中存在来自未感染小鼠的黏附性腹膜渗出细胞是淋巴因子释放的必要条件。该系统可用于定量T细胞对寄生虫抗原的识别，并研究参与寄生虫感染免疫反应的T细胞/抗原呈递细胞相互作用。
