Mogenson G J, Wu M
Brain Res. 1982 Dec 16;253(1-2):243-51. doi: 10.1016/0006-8993(82)90691-6.
The contribution of the mesolimbic dopamine pathway to feeding behavior was investigated in rats in which feeding responses were elicited by electrical stimulation of the medial forebrain bundle at the level of the lateral hypothalamus. Injections of spiroperidol, a dopamine antagonist, into the nucleus accumbens ipsilateral to the stimulating electrode significantly attenuated the elicited feeding responses whereas injecting spiroperidol into the contralateral nucleus accumbens had no effect. The spontaneous discharge rates of neurons of the ventral tegmental area, identified by their electrophysiological characteristics as dopaminergic, were both increased and decreased in response to single pulse stimulation of sites in the medial forebrain bundle from which feeding responses had been elicited. These observations suggest that mesolimbic dopaminergic neurons may have a role in feeding behavior and indicate the need for chronic electrophysiological recording experiments to see whether or not the activity of these neurons is correlated with the initiation of elicited and spontaneous feeding responses.
在大鼠中研究了中脑边缘多巴胺通路对摄食行为的作用，这些大鼠通过电刺激下丘脑外侧水平的内侧前脑束引发摄食反应。向与刺激电极同侧的伏隔核注射多巴胺拮抗剂螺哌啶，可显著减弱引发的摄食反应，而向对侧伏隔核注射螺哌啶则无作用。腹侧被盖区神经元的自发放电率，根据其电生理特征确定为多巴胺能神经元，在对引发摄食反应的内侧前脑束部位进行单脉冲刺激时，其放电率既有增加也有降低。这些观察结果表明，中脑边缘多巴胺能神经元可能在摄食行为中起作用，并表明需要进行慢性电生理记录实验，以观察这些神经元的活动是否与引发的和自发的摄食反应的启动相关。
