Van Best J A
Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Nov;42(5):545-57. doi: 10.1080/09553008214551481.
The radiotoxicity of 123I, 125I and 131I to the thyroid gland was compared in groups of mice subjected to activities of the three isotopes ranging from 10(-2) to 10(2) MBq. The thyroid function was determined fifteen months later on the basis of the 24-hour uptake of a tracer activity of 131I. A reduction in uptake to 20 per cent of the control value for untreated mice was found for mice injected with 35 MBq of 123I, 13 MBq of 125I and 2 . 2 MBq of 131I. On estimating the average absorbed dose in different parts of the thyroid by means of a refined method of dose calculation, that found in the cell layers surrounding the follicles seemed to be most indicative for impairment of thyroid function.
在接受10⁻²至10²MBq这三种同位素活度的小鼠组中，比较了¹²³I、¹²⁵I和¹³¹I对甲状腺的辐射毒性。15个月后，根据¹³¹I示踪剂活度的24小时摄取量来测定甲状腺功能。对于注射了35MBq¹²³I、13MBq¹²⁵I和2.2MBq¹³¹I的小鼠，发现其摄取量降至未处理小鼠对照值的20%。通过一种改进的剂量计算方法估算甲状腺不同部位的平均吸收剂量时，发现卵泡周围细胞层中的剂量似乎最能指示甲状腺功能的损害。
