天然抗性机制可能在抵御化学致癌过程中发挥作用。
Natural resistance mechanisms may play a role in protection against chemical carcinogenesis.
作者信息
Brodt P, Gordon J
出版信息
Cancer Immunol Immunother. 1982;13(2):125-7. doi: 10.1007/BF00205312.
Abstract
Mice deprived of B lymphocytes by the chronic administration of anti-IgM antibodies have been shown to possess a heightened natural resistance (NR) to micro-organisms, to parental bone marrow, and to natural killer (NK)-sensitive tumors in vitro and in vivo. Experiments described in this communication indicate that the latent period of primary tumors induced by the injection of methylcholanthrene (MC) is also prolonged in these mice. This observation suggests that NR mechanisms may provide protection against primary chemically induced tumors.
摘要
通过长期给予抗IgM抗体而缺失B淋巴细胞的小鼠，已被证明在体内外对微生物、亲代骨髓以及对自然杀伤（NK）敏感的肿瘤具有增强的天然抵抗力（NR）。本通讯中描述的实验表明，在这些小鼠中，注射甲基胆蒽（MC）诱导的原发性肿瘤的潜伏期也会延长。这一观察结果表明，NR机制可能提供针对原发性化学诱导肿瘤的保护作用。
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