Ramabadran K, Jacob J J
Jpn J Pharmacol. 1982 Dec;32(6):1059-65. doi: 10.1254/jjp.32.1059.
Low doses of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), quipazine and cyproheptadine produced facilitation of jumping in mice using the hot plate method. Higher doses produced severe motor disturbances which precluded the assessment of effects on nociception. The observed hyperalgesia might be a consequence of diminution of serotoninergic tone resulting either from triggering of presynaptic serotoninergic receptors in the case of 5-MeODMT and quipazine or from the blockade of postsynaptic serotoninergic receptors in the case of cyproheptadine. The 5-MeODMT-induced hyperalgesia was not attenuated by buprenorphine, which under similar conditions antagonized completely the hyperalgesic effects of naloxone; thus, the hyperalgesic effects of 5-MeODMT do not seemingly involve opioidergic receptors.
使用热板法，低剂量的5-甲氧基-N，N-二甲基色胺（5-MeODMT）、喹哌嗪和赛庚啶可促进小鼠跳跃。高剂量则会产生严重的运动障碍，从而无法评估对痛觉的影响。观察到的痛觉过敏可能是由于5-MeODMT和喹哌嗪触发突触前5-羟色胺能受体，或赛庚啶阻断突触后5-羟色胺能受体导致5-羟色胺能张力降低所致。丁丙诺啡并未减弱5-MeODMT诱导的痛觉过敏，而在类似条件下，丁丙诺啡可完全拮抗纳洛酮的痛觉过敏作用；因此，5-MeODMT的痛觉过敏作用似乎不涉及阿片样物质受体。
