Kulkarni S K, Robert R K
Eur J Pharmacol. 1982 Sep 24;83(3-4):325-8. doi: 10.1016/0014-2999(82)90271-0.
Reserpine (4 mg/kg) induced a time-dependent reduction in pain threshold (hyperalgesia) as observed by the tail-flick technique in rats. Serotonin, its precursor 5-hydroxytryptophan or the receptor agonist, quipazine reversed the reserpine-induced hyperalgesia. On the other hand, piribedil, amantadine, imipramine or desipramine treatment failed to reverse the reserpine-induced hyperalgesia. Similarly, intracerebroventricular administration of dopamine or noradrenaline also had no effect on reserpine-induced hyperalgesia. These observations not only suggested a role of serotonin in hyperalgesia but also that reserpine hyperalgesia is suitable for selective study of serotonin-mediated responses in rats.
利血平（4毫克/千克）通过大鼠甩尾技术观察到可诱导痛阈随时间降低（痛觉过敏）。血清素、其前体5-羟色氨酸或受体激动剂喹哌嗪可逆转利血平诱导的痛觉过敏。另一方面，匹立地尔、金刚烷胺、丙咪嗪或地昔帕明治疗未能逆转利血平诱导的痛觉过敏。同样，脑室内注射多巴胺或去甲肾上腺素对利血平诱导的痛觉过敏也没有影响。这些观察结果不仅提示血清素在痛觉过敏中起作用，还表明利血平诱导的痛觉过敏适合于选择性研究大鼠中血清素介导的反应。
