Hinuma Y, Komoda H, Chosa T, Kondo T, Kohakura M, Takenaka T, Kikuchi M, Ichimaru M, Yunoki K, Sato I, Matsuo R, Takiuchi Y, Uchino H, Hanaoka M
Int J Cancer. 1982 Jun 15;29(6):631-5. doi: 10.1002/ijc.2910290606.
A nation-wide sero-epidemiologic survey of adult T-cell leukemia virus (ATLV), detected es anti-ATLA (ATLV-associated antigen), was made in Japan. Sera from adult donors in 15 different locations were screened for anti-ATLA. High incidences (6 to 37%) of antibody-positive donors were found in seven regions, one in northern Japan, and the others in southwestern regions. These areas are ATLV-endemic areas corresponding to ATL-endemic areas. Examination of sera from healthy donors aged 6 to 80 years in ATL-endemic areas showed an age-dependent increase of seropositive donors with a maximum of about 30% at 40 years of age. Anti-ATLA was found in all but two of 142 patients with ATL. Anti-ATLA-positive patients with ATL were mainly found in ATLV-endemic areas, and only a few in ATL-nonendemic areas. Six patients with cutaneous T-cell lymphoma in ATLV-nonendemic areas gave a negative reaction for anti-ATLA. The geometric mean titer of anti-ATLA of patients with ATL was higher than that of healthy donors.
在日本开展了一项针对成人T细胞白血病病毒（ATLV）的全国性血清流行病学调查，检测抗ATLA（ATLV相关抗原）。对来自15个不同地区的成年供血者的血清进行了抗ATLA筛查。在七个地区发现抗体阳性供血者的发生率较高（6%至37%），一个在日本北部，其他在西南部地区。这些地区是与成人T细胞白血病（ATL）流行区相对应的ATLV流行区。对ATL流行区6至80岁健康供血者的血清检测显示，血清阳性供血者随年龄增长而增加，40岁时最高约为30%。在142例ATL患者中，除2例之外均检测到抗ATLA。抗ATLA阳性的ATL患者主要见于ATLV流行区，在ATL非流行区仅有少数。ATLV非流行区的6例皮肤T细胞淋巴瘤患者抗ATLA反应阴性。ATL患者抗ATLA的几何平均滴度高于健康供血者。
