2,4-二硝基苯酚和水杨酸对解偶联剂诱导的非代谢酵母钾离子外流的作用位点
The site of action of 2,4-dinitrophenol and salicylic acid upon the uncoupler-induced K+ efflux from non-metabolizing yeast.
作者信息
Hoeberichts J A, Hulsebos T J, Van Wezenbeek P M, Borst-Pauwels G W
出版信息
Biochim Biophys Acta. 1980;595(1):126-32. doi: 10.1016/0005-2736(80)90254-0.
PMID:6985570
Abstract
Stimulation of K+ efflux from non-metabolizing yeast cells by 2,4-dinitrophenol or by salicylic acid occurs only after accumulation of the compounds into the cells, indicating that the site of action of the uncouplers is inside the cells. A correlation is found between the partition ratio of the lipophilic cation dibenzyldimethylammonium between cells and medium and the rate of K+ efflux.
摘要
2,4-二硝基苯酚或水杨酸刺激非代谢酵母细胞外流钾离子，只有在这些化合物积累到细胞内后才会发生，这表明解偶联剂的作用位点在细胞内部。发现亲脂性阳离子二苄基二甲基铵在细胞与培养基之间的分配系数与钾离子外流速率之间存在相关性。
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