DePirro R, Fusco A, Lauro R, Testa I, Ferreti F, DeMartinis C
Diabetes. 1980 Feb;29(2):96-9. doi: 10.2337/diab.29.2.96.
Insulin binding was studied on circulating erythrocytes isolated from 12 normal and 12 untreated, adult, nonobese, nonketotic, non-insulin-dependent diabetic subjects. Insulin binding in normal subjects was higher than in diabetics (P less than 0.01); binding variation was caused mainly by a reduction in insulin receptor concentration. Insulin binding was inversely correlated with fasting serum insulin levels (R = 0.49; P less than 0.01). The close agreement between the present data and previous data on other cell populations suggests that isolated erythrocytes may be a useful tool in clinical investigations on the human insulin receptor.
对从12名正常受试者以及12名未经治疗的成年、非肥胖、非酮症、非胰岛素依赖型糖尿病患者中分离出的循环红细胞进行了胰岛素结合研究。正常受试者的胰岛素结合水平高于糖尿病患者（P<0.01）；结合差异主要是由胰岛素受体浓度降低引起的。胰岛素结合与空腹血清胰岛素水平呈负相关（R = 0.49；P<0.01）。目前的数据与之前关于其他细胞群体的数据高度一致，这表明分离出的红细胞可能是人类胰岛素受体临床研究中的一种有用工具。
