Akrami C, Falkner B, Gould A B, DeClement F A, Bendlin A
J Trauma. 1980 Feb;20(2):130-4. doi: 10.1097/00005373-198002000-00005.
Children with thermal injuries have an unusually high incidence of hypertension during the course of their postinjury care. This study investigates the activity of the renin angiotensin system during the postinjury period. Sustained hypertension occurred in three of 11 children studied. All three cases demonstrated markedly elevated plasma renin levels (greater than 2IRU x 10(4)). Two of five children with episodes of hypertension also demonstrated abnormally high plasma renin. No normotensive patients had markedly elevated renin levels. The mechanism directing elevated renin secretion may be related to changes in regional blood flow in addition to the stimulus of increased catecholamine activity. A markedly elevated plasma renin may be predictive of the development of hypertension.
热损伤儿童在伤后护理过程中高血压发病率异常高。本研究调查伤后肾素 - 血管紧张素系统的活性。在11名接受研究的儿童中，有3名出现持续性高血压。所有这3例均显示血浆肾素水平显著升高（大于2IRU×10⁴）。5例有高血压发作的儿童中有2例也显示血浆肾素异常高。无血压正常的患者肾素水平显著升高。除了儿茶酚胺活性增加的刺激外，导致肾素分泌升高的机制可能与局部血流变化有关。血浆肾素显著升高可能预示高血压的发生。
