Naeije R, Salingret E, Clumeck N, De Troyer A, Devis G
Br Med J. 1978 Sep 2;2(6138):659-60. doi: 10.1136/bmj.2.6138.659.
Fifty-eight patients with mild to moderately severe acute pancreatitis were randomly allocated to treatment with or without nasogastric suction (27 and 31 patients respectively). Intravenous fluids and pethidine hydrochloride were also given. The two groups were comparable clinically at the start of the study. There were no differences between the two groups in the mean duration of the following features: abdominal pain or tenderness; absence of bowel movements; raised serum amylase concentration; time to resumption of oral feeding; and days in hospital. Prolonged hyperamylasaemia (serum amylase greater than 0.33 mU/l) occurred in one patient in the suction group and in three patients in the non-suction group. A mild recurrence of abdominal pain after resumption of oral feeding occurred in three patients in the suction group and in two patients in the non-suction group. Two patients in the suction group developed overt consumption coagulopathy and two others pulmonary complications. No patient in the non-suction group had complications. The findings suggest that most patients with mild to moderately severe acute pancreatitis do not benefit from nasogastric suction. The procedure should be elective rather than mandatory in treating this condition.
58例轻至中度重症急性胰腺炎患者被随机分为两组,分别接受或不接受鼻胃管抽吸治疗(每组分别为27例和31例)。同时给予静脉补液和盐酸哌替啶。研究开始时,两组在临床上具有可比性。两组在以下特征的平均持续时间方面无差异:腹痛或压痛;无排便;血清淀粉酶浓度升高;恢复经口进食的时间;以及住院天数。鼻胃管抽吸组有1例患者出现持续性高淀粉酶血症(血清淀粉酶大于0.33 mU/l),非鼻胃管抽吸组有3例。鼻胃管抽吸组有3例患者在恢复经口进食后出现轻度腹痛复发,非鼻胃管抽吸组有2例。鼻胃管抽吸组有2例患者发生明显的消耗性凝血病,另有2例出现肺部并发症。非鼻胃管抽吸组无患者出现并发症。研究结果表明,大多数轻至中度重症急性胰腺炎患者无法从鼻胃管抽吸中获益。在治疗这种疾病时,该操作应是选择性的而非强制性的。