浆细胞异常增生症患者的循环免疫球蛋白分泌细胞

Circulating immunoglobulin-secreting cells in patients with plasma cell dyscrasia.

作者信息

Shimizu K, Murate T, Kunii A

出版信息

Blood. 1980 Apr;55(4):590-4.

Abstract

Immunoglobulin-secreting cells (ISC) in peripheral blood mononuclear cells (PBM) isolated from patients with plasma cell dyscrasia of various stages were studied using reverse hemolytic plaque assay. Normal healthy individuals contained 35 +/- 16 ISC/10(5) PBM. Aleukemic or subleukemic patients with overt myeloma contained 825 +/- 713 ISC, whereas leukemic patients contained 12,675 +/- 2520 ISC. Patients of premyelomatous stage, however, contained ISC/10(5) PBM of normal range. The relationship between ISC and clinical stage or laboratory data is discussed.

摘要

采用反向溶血空斑试验，对从处于不同阶段浆细胞恶液质患者分离出的外周血单个核细胞（PBM）中的免疫球蛋白分泌细胞（ISC）进行了研究。正常健康个体每10⁵个PBM中含有35±16个ISC。无症状性或亚白血病性显性骨髓瘤患者每10⁵个PBM中含有825±713个ISC，而白血病患者每10⁵个PBM中含有12,675±2520个ISC。然而，骨髓瘤前期患者每10⁵个PBM中的ISC数量处于正常范围。文中讨论了ISC与临床分期或实验室数据之间的关系。

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