Chretien J H, Esswein J G, Sharpe L M, Kiely J J, Lyddon F E
Int J Dermatol. 1980 Jan-Feb;19(1):51-4. doi: 10.1111/j.1365-4362.1980.tb01997.x.
One hundred fifty-one patients with tinea pedis participated in a double-blind study to assess the efficacy and safety of a powder containing undecylenic acid 2% and zinc undecylenate 20% versus a placebo powder. Patients were assigned to apply twice-daily applications of either active powder or placebo for a period of 4 weeks. Trichophyton rubrum or Trichophyton mentagrophytes were isolated from pretreatment cultures of 85 patients. Of these, 88% treated with active powder had negative cultures after 4 weeks compared with 17% of those treated with placebo powder (p less than 0.001). Fungus was identified in potassium hydroxide (KOH) treated skin scrapings of all 151 patients before treatment. Of those treated with active powder, 80% were KOH negative after 4 weeks compared with 49% of those treated with placebow powder (p = 0.001). Erythema and scaling were significantly improved by therapy with active powder, as were subjective evaluations of itching and burning. There were no side-effects or adverse reactions to undecylenic acid and its zinc salt.
151名足癣患者参与了一项双盲研究，以评估一种含有2%十一烯酸和20%十一烯酸锌的粉剂与安慰剂粉剂的疗效和安全性。患者被分配每天两次涂抹活性粉剂或安慰剂，为期4周。85名患者的治疗前培养物中分离出红色毛癣菌或须癣毛癣菌。其中，4周后，88%接受活性粉剂治疗的患者培养结果为阴性，而接受安慰剂粉剂治疗的患者中这一比例为17%（p<0.001）。治疗前，在所有151名患者用氢氧化钾（KOH）处理的皮肤刮片中均鉴定出真菌。4周后，接受活性粉剂治疗的患者中80%的KOH检测结果为阴性，而接受安慰剂粉剂治疗的患者中这一比例为49%（p = 0.001）。活性粉剂治疗可显著改善红斑和脱屑，瘙痒和烧灼感的主观评估结果也是如此。十一烯酸及其锌盐没有副作用或不良反应。
