甲醛对酵母造成损伤的生化分析。
Biochemical analysis of damage induced in yeast by formaldehyde.
作者信息
Magaña-Schwencke N, Moustacchi E
出版信息
Mutat Res. 1980 Mar;70(1):29-35. doi: 10.1016/0027-5107(80)90055-x.
PMID:6988706
Abstract
Cross-links between DNA and proteins were induced by formaldehyde treatment in yeast cells. This damage can be repaired by post-treatment incubation of cells or protoplasts in nutrient medium. This repair was observed for wild-type cells as well as for a UV-sensitive, excision-deficient mutant (rad1-3), also sensitive to the lethal effect of formaldehyde.
摘要
在酵母细胞中，甲醛处理可诱导DNA与蛋白质之间形成交联。这种损伤可通过将细胞或原生质体在营养培养基中进行后处理孵育来修复。野生型细胞以及对紫外线敏感、切除缺陷型突变体（rad1-3）（对甲醛的致死效应也敏感）都观察到了这种修复情况。
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