Shimamoto K, Tanaka S, Ando T, Nakao T, Nakahashi Y, Miyahara M
Tohoku J Exp Med. 1980 Jan;130(1):71-8. doi: 10.1620/tjem.130.71.
In order to investigate the etiology of idiopathic edema, clinical findings and endocrinological abnormalities were analyzed in twenty-seven patients, and the following results were obtained. An easy occurrence of subcutaneous bleeding and positive Rumpel-Leede phenomenon were observed in the majority of the patients. ADH, plasma renin activity and plasma aldosterone concentration in the patients did not show abnormalities following water loading in the supine position when compared with normal controls. But the results obtained in the present study suggested that they might contribute to water and sodium retention in the upright position. In the patients, plasma prolactin levels were not decreased, but rather increased and urinary excretion of kallikrein and kinin was reduced significantly after water loading in the upright position. Thus, prolactin and urinary kallikrein-kinin system might also contribute to water and sodium retention in idiopathic edema, directly or indirectly through the augmentation of the action of ADH and of aldosterone. It was concluded that the increased vascular permeability and endocrinological polyfactors play a role, in a cooperative fashion, in the mechanism of this disease.
为了研究特发性水肿的病因，对27例患者的临床症状和内分泌异常情况进行了分析，得出以下结果。大多数患者出现皮下出血容易和Rumpel-Leede现象阳性。与正常对照组相比，患者在仰卧位水负荷后抗利尿激素（ADH）、血浆肾素活性和血浆醛固酮浓度未显示异常。但本研究结果表明，它们可能在直立位时导致水钠潴留。在患者中，血浆催乳素水平未降低，反而升高，且在直立位水负荷后激肽释放酶和激肽的尿排泄显著减少。因此，催乳素和尿激肽释放酶-激肽系统也可能直接或通过增强ADH和醛固酮的作用间接导致特发性水肿中的水钠潴留。得出结论，血管通透性增加和内分泌多因素以协同方式在本病机制中起作用。
