Auger P, Marquis G, Dallaire L, Montplaisir S, Ghoubril S
Am J Obstet Gynecol. 1980 Apr 15;136(8):1075-9. doi: 10.1016/0002-9378(80)90641-9.
With a sensitive indirect immunofluorescent technique, we studied the antibody response to Candida albicans in 150 human amniotic fluid (AF) specimens at 15 to 18 weeks' gestation. Specific IgG was detected in 94.7% of the samples and specific IgA, in 98%, while 1.3% were negative in both tests. A comparison of the mean ratio of anticandidal titers (IgA/IgG) in AF and human serum indicated a predominance of IgA activity in AF and the reverse in serum (2.01 versus 0.66, p less than 0.001). There was no correlation between IgG and corresponding IgA titers, which supports the fetal origin of IgA. Humoral immunity alone had no discernible influence on the growth of C. albicans in midtrimester AF. It is suggested that the synthesis of specific IgA is genetically determined because it presumably offers some functional advantage over transmitted maternal IgG in the local defensive mechanisms of the amniotic cavity.
我们采用灵敏的间接免疫荧光技术，研究了150例妊娠15至18周的人羊水（AF）标本对白色念珠菌的抗体反应。94.7%的样本检测到特异性IgG，98%检测到特异性IgA，1.3%的样本两项检测均为阴性。羊水与人体血清中抗念珠菌滴度平均比值（IgA/IgG）的比较表明，羊水中IgA活性占优势，而血清中则相反（2.01对0.66，p<0.001）。IgG和相应的IgA滴度之间没有相关性，这支持了IgA的胎儿来源。仅体液免疫对孕中期羊水中白色念珠菌的生长没有明显影响。提示特异性IgA的合成是由基因决定的，因为在羊膜腔的局部防御机制中，它可能比母体传递的IgG具有某些功能优势。
