Giugliano D, Luyckx A S, Lefebvre P J
J Endocrinol Invest. 1980 Jan-Mar;3(1):19-23. doi: 10.1007/BF03348212.
Plasma C-peptide concentrations have been determined in the basal state and in response to intravenous arginine in 10 insulin-dependent diabetics. Five patients had fasting C-peptide levels above 0.08 pmol/ml and responded to the arginine infusion with a rise in C-peptide levels of more than 0.2 pmol/ml (responsive diabetics). The remaining 5 patients had fasting C-peptide below 0.03 pmol/ml and showed no C-peptide response to arginine (nonresponsive diabetics). Fasting blood glucose and the rise in blood glucose in response to arginine were higher in non-responsive than in responsive diabetics. The magnitude of blood glucose rise in response to arginine was inversely correlated with increments in plasma C-peptide. In addition, the fasting levels of FFA and 3-hydroxybutyrate were significantly lower in C-peptide responsive than in nonresponsive patients. These data give further support to the concept that measurements of fasting plasma C-peptide permit to distinguish secretors from nonsecretors, and demonstrate that residual beta-cell function is associated with a lesser degree of aminoacid-induced hyperglycemia.
已测定了10例胰岛素依赖型糖尿病患者的基础状态下及静脉注射精氨酸后的血浆C肽浓度。5例患者空腹C肽水平高于0.08 pmol/ml，对精氨酸输注的反应是C肽水平升高超过0.2 pmol/ml（反应性糖尿病患者）。其余5例患者空腹C肽低于0.03 pmol/ml，对精氨酸无C肽反应（无反应性糖尿病患者）。无反应性糖尿病患者的空腹血糖及精氨酸刺激后的血糖升高幅度高于反应性糖尿病患者。精氨酸刺激后血糖升高幅度与血浆C肽增量呈负相关。此外，C肽反应性患者的空腹游离脂肪酸（FFA）和3-羟基丁酸水平显著低于无反应性患者。这些数据进一步支持了空腹血浆C肽测定可区分分泌者与非分泌者的概念，并表明残余β细胞功能与氨基酸诱导的高血糖程度较轻有关。
