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内毒素诱导小鼠脾脏白髓中过氧化物酶阳性细胞的出现。

Endotoxin-induced appearance of peroxidase-positive cells in the white pulp of the mouse spleen.

作者信息

Jasani B, Stark J M

出版信息

Immunology. 1980 Apr;39(4):535-9.

PMID:6991399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458014/
Abstract

Endotoxin (1-10 microgram intravenously) increased the number of strongly peroxidase-positive cells in the white pulp of the mouse spleen, demonstrable by the Graham-Karnovsky technique. The increase was greatest after 10 h, the cells being found most frequently around the central vessels of the white pulp. The appearance of such cells at this critical immunological site may relate to the known adjuvant activity of endotoxin in promoting immune responses against protein antigens.

摘要

内毒素（静脉注射1 - 10微克）可增加小鼠脾脏白髓中强过氧化物酶阳性细胞的数量，这可通过格雷厄姆 - 卡诺夫斯基技术证实。10小时后增加最为显著，这些细胞最常见于白髓中央血管周围。在这个关键免疫部位出现此类细胞可能与内毒素促进针对蛋白质抗原的免疫反应的已知佐剂活性有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c835/1458014/a06224683c6e/immunology00257-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c835/1458014/a06224683c6e/immunology00257-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c835/1458014/a06224683c6e/immunology00257-0078-a.jpg

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本文引用的文献

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Studies on the adjuvant action of bacterial endotoxins on antibody formation. I. Time limitation of enhancing effect and restoration of antibody formation in x-irradiated rabbits.细菌内毒素对抗体形成的佐剂作用研究。I. 增强效应的时间限制及X射线照射兔体内抗体形成的恢复
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Studies on the O antigen of Salmonella typhosa. V. Enhancement of antibody response to protein antigens by the purified lipopolysaccharide.伤寒沙门氏菌O抗原的研究。V. 纯化脂多糖增强对蛋白质抗原的抗体反应。
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Immunogenicity of lipid-conjugated antigens. II. Anti-complementary activity and antigen trapping in the spleen.
脂质偶联抗原的免疫原性。II. 抗补体活性及脾脏中的抗原捕获
Immunology. 1980 Mar;39(3):353-60.
4
The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.注入的辣根过氧化物酶在小鼠肾近端小管吸收的早期阶段：一种新技术的超微结构细胞化学研究
J Histochem Cytochem. 1966 Apr;14(4):291-302. doi: 10.1177/14.4.291.
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Antigens in immunity. XII. Antigen trapping in the spleen.免疫中的抗原。十二、脾脏中的抗原捕获
Int Arch Allergy Appl Immunol. 1966;29(4):368-83.
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A role of macrophages in the stimulation of immune responses by adjuvants.巨噬细胞在佐剂刺激免疫反应中的作用。
J Immunol. 1969 Jul;103(1):71-8.
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Morphology and peroxidase cytochemistry of mouse promonocytes, monocytes, and macrophages.小鼠前单核细胞、单核细胞和巨噬细胞的形态学及过氧化物酶细胞化学
J Exp Med. 1970 Oct 1;132(4):794-812. doi: 10.1084/jem.132.4.794.
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The immunogenicity of antigen bound to the plasma membrane of macrophages.与巨噬细胞质膜结合的抗原的免疫原性。
J Exp Med. 1970 Apr 1;131(4):711-25. doi: 10.1084/jem.131.4.711.
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A study of the localisation of a protein antigen in the chicken spleen and its relation to the formation of germinal centres.一项关于鸡脾脏中蛋白质抗原定位及其与生发中心形成关系的研究。
J Med Microbiol. 1970 Feb;3(1):65-83. doi: 10.1099/00222615-3-1-65.
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Mode of action of adjuvants: effects on antibody responses to macrophage-associated bovine serum albumin.佐剂的作用方式：对巨噬细胞相关牛血清白蛋白抗体反应的影响
J Immunol. 1970 Jan;104(1):128-39.