Schroff R W, Heise E R, Myrvik Q N, Shannon B T
Infect Immun. 1980 Apr;28(1):269-76. doi: 10.1128/iai.28.1.269-276.1980.
The relationship between dermal delayed hypersensitivity (DH) and granulomatous hypersensitivity was studied in rabbits sensitized with killed mycobacteria. Specific antigen challenge of sensitized animals resulted in extensive pulmonary granulomatous inflammation and induced suppression of both dermal DH and dermal granuloma formation. Whereas suppression of DH was concomitant with pulmonary granuloma formation, as is the case in a number of granulomatous diseases, a causal relationship between the two did not exist. Both DH and dermal granulomatous hypersensitivity were significantly suppressed whether or not the antigen challenge was of a granulomagenic (particulate) or nongranulomagenic (soluble) form. The data presented indicate that granulomatous hypersensitivity and DH are selectively suppressed with regard to different anatomical sites.
在用灭活分枝杆菌致敏的兔子中研究了皮肤迟发型超敏反应（DH）与肉芽肿性超敏反应之间的关系。对致敏动物进行特异性抗原攻击会导致广泛的肺部肉芽肿性炎症，并诱导皮肤DH和皮肤肉芽肿形成的抑制。虽然DH的抑制与肺部肉芽肿形成同时发生，就像许多肉芽肿性疾病那样，但两者之间不存在因果关系。无论抗原攻击是肉芽肿性（颗粒状）还是非肉芽肿性（可溶性）形式，DH和皮肤肉芽肿性超敏反应均被显著抑制。所呈现的数据表明，肉芽肿性超敏反应和DH在不同解剖部位受到选择性抑制。
