索状因子（海藻糖-6,6'-二霉菌酸酯）在兔过敏性肉芽肿形成中的作用。
Role of cord factor (trehalose-6,6'-dimycolate) in allergic granuloma formation in rabbits.
作者信息
Moore V L, Myrvik Q N, Kato M
出版信息
Infect Immun. 1972 Jul;6(1):5-8. doi: 10.1128/iai.6.1.5-8.1972.
Abstract
The role of cord factor in BCG-induced pulmonary granulomas and local pulmonary delayed hypersensitivity (DH) was evaluated. Cord factor did not induce pulmonary granulomas comparable to those induced by killed BCG. The compound did not induce pulmonary DH that could be elicited by itself, purified protein derivative, or BCG. Cord factor-injected animals did not develop an accelerated pulmonary granulomatous response after challenge with killed BCG. Finally, cord factor did not elicit local pulmonary DH in BCG-sensitized animals. These results are discussed in relation to cord factor's role in antimicrobial immunity, granuloma formation, and antitumor immunity.
摘要
评估了索状因子在卡介苗诱导的肺部肉芽肿和局部肺部迟发型超敏反应（DH）中的作用。索状因子不能诱导出与灭活卡介苗所诱导的相当的肺部肉芽肿。该化合物不能诱导出可由其自身、纯化蛋白衍生物或卡介苗引发的肺部DH。注射索状因子的动物在接受灭活卡介苗攻击后并未出现加速的肺部肉芽肿反应。最后，索状因子在卡介苗致敏的动物中不能引发局部肺部DH。结合索状因子在抗微生物免疫、肉芽肿形成和抗肿瘤免疫中的作用对这些结果进行了讨论。
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