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1
Lymphocyte alpha-actinin. Relationship to cell membrane and co-capping with surface receptors.淋巴细胞α-辅肌动蛋白。与细胞膜的关系以及与表面受体的共同帽化。
J Cell Biol. 1980 Feb;84(2):305-14. doi: 10.1083/jcb.84.2.305.
2
Comparison of intestinal brush-border 95-Kdalton polypeptide and alpha-actinins.肠道刷状缘95千道尔顿多肽与α-辅肌动蛋白的比较
J Cell Biol. 1980 Mar;84(3):655-67. doi: 10.1083/jcb.84.3.655.
3
Capping of cholera toxin-ganglioside GM1 complexes on mouse lymphocytes is accompanied by co-capping of alpha-actinin.霍乱毒素-神经节苷脂GM1复合物在小鼠淋巴细胞上的封帽伴随着α-辅肌动蛋白的共同封帽。
J Cell Biol. 1983 Aug;97(2):447-54. doi: 10.1083/jcb.97.2.447.
4
The participation of alpha-actinin in the capping of cell membrane components.α-辅肌动蛋白在细胞膜成分封端过程中的参与。
Cell. 1979 Jan;16(1):213-22. doi: 10.1016/0092-8674(79)90202-2.
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Double-immunofluorescent staining of isolated smooth muscle cells. I. preparation of anti-chicken gizzard alpha-actinin and its use with anti-chicken gizzard myosin for co-localization of alpha-actinin and myosin in chicken gizzard cells.分离平滑肌细胞的双重免疫荧光染色。I. 抗鸡胗α-辅肌动蛋白的制备及其与抗鸡胗肌球蛋白一起用于鸡胗细胞中α-辅肌动蛋白和肌球蛋白的共定位。
Histochemistry. 1980;69(2):113-30. doi: 10.1007/BF00533128.
6
Detection of a specific isoform of alpha-actinin with antisera directed against dystrophin.用抗肌营养不良蛋白的抗血清检测α-辅肌动蛋白的一种特定同工型。
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7
The association of alpha-actinin and clathrin with the plasma membrane.α-辅肌动蛋白和网格蛋白与质膜的关联。
Prog Clin Biol Res. 1980;41:907-24.
8
Peripheral and integral proteins of human blood platelet membranes. alpha-Actinin is not identical to glycoprotein III.人血小板膜的外周蛋白和整合蛋白。α-辅肌动蛋白与糖蛋白III不同。
Biochim Biophys Acta. 1982 Jun 4;704(2):333-44. doi: 10.1016/0167-4838(82)90163-7.
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AAMP, a newly identified protein, shares a common epitope with alpha-actinin and a fast skeletal muscle fiber protein.AAMP是一种新发现的蛋白质，它与α-辅肌动蛋白和一种快速骨骼肌纤维蛋白具有共同的表位。
Exp Cell Res. 1996 Jun 15;225(2):306-14. doi: 10.1006/excr.1996.0181.
10
Immunocytochemical localization of alpha-actinin in intestinal epithelial cells.α-辅肌动蛋白在肠上皮细胞中的免疫细胞化学定位
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2833-7. doi: 10.1073/pnas.76.6.2833.

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1
TCR Triggering Induces the Formation of Lck-RACK1-Actinin-1 Multiprotein Network Affecting Lck Redistribution.TCR触发诱导形成影响Lck重新分布的Lck-RACK1-肌动蛋白-1多蛋白网络。
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T Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors.T淋巴细胞迁移：一部由肌动蛋白及相关“演员”主演的动作片。
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Consequences of alkaline treatment for the ultrastructure of the acetylcholine-receptor-rich membranes from Torpedo marmorata electric organ.碱性处理对电鳐电器官富含乙酰胆碱受体的膜超微结构的影响。
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Reversible translocation of cytoplasmic actin into the nucleus caused by dimethyl sulfoxide.二甲基亚砜引起的细胞质肌动蛋白向细胞核的可逆易位。
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Kinetic evidence for a common mechanism of capping on lymphocytes.淋巴细胞上帽化共同机制的动力学证据。
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6
Interaction of alpha-actinin and vinculin with actin: opposite effects on filament network formation.α-辅肌动蛋白和纽蛋白与肌动蛋白的相互作用：对细丝网络形成的相反作用。
Proc Natl Acad Sci U S A. 1981 May;78(5):3005-9. doi: 10.1073/pnas.78.5.3005.
7
Capping of cholera toxin-ganglioside GM1 complexes on mouse lymphocytes is accompanied by co-capping of alpha-actinin.霍乱毒素-神经节苷脂GM1复合物在小鼠淋巴细胞上的封帽伴随着α-辅肌动蛋白的共同封帽。
J Cell Biol. 1983 Aug;97(2):447-54. doi: 10.1083/jcb.97.2.447.
8
Differential expression and distribution of chicken skeletal- and smooth-muscle-type alpha-actinins during myogenesis in culture.培养过程中鸡骨骼肌型和平滑肌型α-辅肌动蛋白在肌生成过程中的差异表达与分布
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Differences in the stress fibers between fibroblasts and epithelial cells.成纤维细胞和上皮细胞之间应力纤维的差异。
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10
Redistribution of fodrin (a component of the cortical cytoplasm) accompanying capping of cell surface molecules.伴随细胞表面分子帽化的血影蛋白（皮质细胞质的一种成分）重新分布。
Proc Natl Acad Sci U S A. 1983 Jan;80(1):191-5. doi: 10.1073/pnas.80.1.191.

本文引用的文献

1
SPECIFICITY OF ISOANTISERA AGAINST LEUKAEMIC AND THYMIC LYMPHOCYTES.抗白血病和胸腺淋巴细胞同种抗血清的特异性
Nature. 1963 Dec 28;200:1332-3. doi: 10.1038/2001332b0.
2
Studies on purified -actinin. I. Effect of temperature and tropomyosin on the -actinin-F-actin interaction.关于纯化的肌动蛋白结合蛋白的研究。I. 温度和原肌球蛋白对肌动蛋白结合蛋白与F-肌动蛋白相互作用的影响。
J Mol Biol. 1972 Jun 28;67(3):469-88. doi: 10.1016/0022-2836(72)90464-0.
3
A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.一种用于检测聚丙烯酰胺凝胶中氚标记蛋白质和核酸的胶片检测方法。
Eur J Biochem. 1974 Jul 1;46(1):83-8. doi: 10.1111/j.1432-1033.1974.tb03599.x.
4
Inhibition and reversal of capping by cytochalasin B, vinblastine and colchicine.细胞松弛素B、长春花碱和秋水仙碱对帽化的抑制与逆转作用
Nature. 1974 Jul 5;250(461):54-6. doi: 10.1038/250054a0.
5
Antilymphocyte antibody purified by immunoabsorption and elution.通过免疫吸附和洗脱纯化的抗淋巴细胞抗体。
Clin Exp Immunol. 1974 Mar;16(3):367-74.
6
Preparation and properties of lymphocyte plasma membrane.淋巴细胞质膜的制备与特性
Contemp Top Mol Immunol. 1974;3:27-56. doi: 10.1007/978-1-4684-2838-4_2.
7
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
8
Complete amino-acid sequence of actin of rabbit skeletal muscle.兔骨骼肌肌动蛋白的完整氨基酸序列。
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2687-91. doi: 10.1073/pnas.70.9.2687.
9
Receptor mobility and receptor-cytoplasmic interactions in lymphocytes.淋巴细胞中的受体移动性与受体-细胞质相互作用
Proc Natl Acad Sci U S A. 1973 May;70(5):1442-6. doi: 10.1073/pnas.70.5.1442.
10
Comparative studies of -actinin from porcine cardiac and skeletal muscle.猪心肌和骨骼肌中α-辅肌动蛋白的比较研究。
Biochim Biophys Acta. 1973 Jan 25;295(1):208-24. doi: 10.1016/0005-2795(73)90088-3.

淋巴细胞α-辅肌动蛋白。与细胞膜的关系以及与表面受体的共同帽化。

Lymphocyte alpha-actinin. Relationship to cell membrane and co-capping with surface receptors.

作者信息

Hoessli D, Rungger-Brändle E, Jockusch B M, Gabbiani G

出版信息

J Cell Biol. 1980 Feb;84(2):305-14. doi: 10.1083/jcb.84.2.305.

DOI:10.1083/jcb.84.2.305
PMID:6991509
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2110540/
Abstract

Mouse spleen lymphocytes synthesize a protein which comigrates with skeletal muscle alpha-actinin on two-dimensional gel electrophoresis and is immunoprecipitated by an antibody directed against skeletal muscle alpha-actinin. Mouse lymphocyte alpha-actinin is present in membrane fractions, and is immunoprecipitated from lymphocyte detergent lysates by an antiserum made against these purified membranes. The anti-alpha-actinin activity of this antiserum is not adsorbed after incubation with fixed intact lymphocytes. Lymphocyte alpha-actinin does not bind concanavalin A and it is inaccessible to lactoperoxidase-catalyzed surface iodination. Double immunofluorescence shows that alpha-actinin moves concurrently along the cell membrane with redistributed surface immunoglobulins and Thy-1 antigen, and remains associated up to 30 min with surface aggregates of these receptors. Our results suggest that lymphocyte alpha-actinin, as defined by molecular weight and cross reactivity with the antibody against the muscle protein, (a) is associated with the cell membrane, (b) is not expressed at the cell surface, and (c) participates in the movement of surface receptors.

摘要

小鼠脾淋巴细胞合成一种蛋白质，该蛋白质在二维凝胶电泳上与骨骼肌α-辅肌动蛋白迁移率相同，且能被抗骨骼肌α-辅肌动蛋白的抗体免疫沉淀。小鼠淋巴细胞α-辅肌动蛋白存在于膜组分中，并且能从淋巴细胞去污剂裂解物中被针对这些纯化膜制备的抗血清免疫沉淀。该抗血清与固定的完整淋巴细胞孵育后，其抗α-辅肌动蛋白活性不被吸附。淋巴细胞α-辅肌动蛋白不结合伴刀豆球蛋白A，且不能被乳过氧化物酶催化的表面碘化作用所作用。双重免疫荧光显示α-辅肌动蛋白与重新分布的表面免疫球蛋白和Thy-1抗原同时沿着细胞膜移动，并与这些受体的表面聚集体保持结合长达30分钟。我们的结果表明，根据分子量和与抗肌肉蛋白抗体的交叉反应性所定义的淋巴细胞α-辅肌动蛋白，(a) 与细胞膜相关，(b) 不在细胞表面表达，并且 (c) 参与表面受体的移动。