香豆霉素消除大肠杆菌K12质粒
Curing of Escherichia coli K12 plasmids by coumermycin.
作者信息
Danilevskaya O N, Gragerov A I
出版信息
Mol Gen Genet. 1980 Apr;178(1):233-5. doi: 10.1007/BF00267235.
PMID:6991878
Abstract
Low concentrations of the antibiotic coumermycin A1, the inhibitor of bacterial DNA gyrase, effectively eliminate pBR322, pMB9 and other ColE 1 related plasmids from E. coli K12 strains. The curing action of antibiotic seems to result from the plasmid degradation and not just from the inhibition of replication.
摘要
低浓度的抗生素香豆霉素A1（一种细菌DNA促旋酶抑制剂）能有效从大肠杆菌K12菌株中消除pBR322、pMB9及其他与ColE1相关的质粒。抗生素的消除作用似乎源于质粒降解，而不仅仅是抑制复制。
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