利多卡因可增加大鼠体内的前列环素。

Lidocaine increases prostacyclin in the rat.

作者信息

Casey L C, Armstrong M C, Fletcher J R, Ramwell P W

出版信息

Prostaglandins. 1980 Jun;19(6):977-84. doi: 10.1016/0090-6980(80)90130-6.

Abstract

In the rat, the effect of intravenous lidocaine was evaluated on plasma prostacyclin concentration as well as the concentration of prostacyclin in aortic ring incubation chambers and in the effluent of isolated perfused lungs. Prostacyclin was assayed using a radioimmunoassay for its stable product 6-Keto PGF1 alpha. Lidocaine in therapeutic doses (2 mg/kg) will significantly increase 6-Keto PGF1 alpha in plasma as well as in aortic ring incubation chambers and in the effluent of isolated perfused lungs when compared to saline treated controls.

摘要

在大鼠中，评估了静脉注射利多卡因对血浆前列环素浓度以及主动脉环孵育室和离体灌注肺流出液中前列环素浓度的影响。使用放射免疫分析法测定前列环素的稳定产物6-酮-前列腺素F1α来检测前列环素。与生理盐水处理的对照组相比，治疗剂量（2mg/kg）的利多卡因将显著增加血浆、主动脉环孵育室和离体灌注肺流出液中的6-酮-前列腺素F1α。