Svensson B, Sturfelt G
Scand J Rheumatol Suppl. 1980;31:43-52.
Studies on glass adherence and spreading of normal blood monocytes in presence of sera from patients with systemic lupus erythematosus (SLE) were performed. Spreading was estimated by measuring the cell diameters with a microscale in a phase contrast microscope. Glass adherence (number of glass adherent cells per cultivation chamber) and spreading were found to be significantly reduced in presence of SLE-sera. Furthermore, in presence of these SLE-sera the monocytes formed clusters, which resolved after addition of normal sera. It is suggested that these observations may reflect a disturbance of monocyte membrane function possibly induced by immune complexes or through depletion of complement components in sera from patients with active SLE.
开展了关于在系统性红斑狼疮（SLE）患者血清存在的情况下正常血液单核细胞的玻璃黏附及铺展情况的研究。通过在相差显微镜下用测微计测量细胞直径来评估铺展情况。发现在SLE血清存在的情况下，玻璃黏附（每个培养室中玻璃黏附细胞的数量）及铺展显著降低。此外，在这些SLE血清存在的情况下，单核细胞形成聚集体，在加入正常血清后分散开来。提示这些观察结果可能反映了单核细胞膜功能的紊乱，这可能是由免疫复合物或通过活动性SLE患者血清中补体成分的消耗所诱导的。
