Brailski Kh, Matov V, Dimitrov B, Bakalov V, Bozhiianov V
Vutr Boles. 1980;19(2):60-8.
The therapeutic effect of four new variants of the preparation Almagel was studied in 100 patients with duodenal ulcer (25 patients in each group were examined)---Flatugel, Flatugel A, Almagel-Neo. The pains, with the treatment faded away in 60 to 68% and abated in 25 to 32% of the treated in the separate groups. As compared with the control group, the symptom constipation was influenced in a higher per cent by the new preparations, explained by the twice higher dose of magnesium hydroxide in the new almagel derivatives. Flatugel A and almagel A-neo had the best upon vomiting, due to the anesthesin, contained in them. In half of the patients, the clinical symptoms disappeared during the first week after the initiation of the treatment and after its termination the clinical manifestations remained unaffected in only 8% of the patients. After the 20-day treatment with the new modifications of almagel, the ulcer niche disappeared in 25-29% and its dimensions were reduced in 30-50%. No significant differences were established as regards the effect upon the rest of the clinical symptoms and ulcer niche among the new preparations themselves and each separate preparations as compared with the control group. The new almagel modifications show a tendency of reduction of gastric secretion and acidity 12 hours after the termination of the treatment as compared with the same prior to treatment, but the differences are statistically insignificant. The new variants of almagel have a pleasant taste, they are taken with pleasure and give no toxic and allergic side effects.
对100例十二指肠溃疡患者（每组检查25例）研究了制剂Almagel的四种新变体——Flatugel、Flatugel A、Almagel-Neo的治疗效果。在各单独组中，治疗后疼痛消失的患者占60%至68%，减轻的患者占25%至32%。与对照组相比，新制剂对便秘症状的影响比例更高，这是由于新的Almagel衍生物中氢氧化镁剂量增加了两倍。Flatugel A和Almagel A-neo对呕吐的效果最佳，这是因为它们含有麻醉剂。一半的患者在治疗开始后的第一周内临床症状消失，治疗结束后仅8%的患者临床表现未受影响。用Almagel的新变体进行20天治疗后，溃疡龛消失的比例为25%至29%，其尺寸缩小的比例为30%至50%。新制剂本身之间以及与对照组相比，各单独制剂对其余临床症状和溃疡龛的影响未发现显著差异。与治疗前相比，治疗结束12小时后，Almagel的新变体显示出胃分泌和酸度降低的趋势，但差异无统计学意义。Almagel的新变体味道宜人，患者乐于服用，且无毒性和过敏副作用。
