Mehta J, Mehta P, Pepine C J
Circulation. 1978 Nov;58(5):881-6. doi: 10.1161/01.cir.58.5.881.
We studied 16 patients with coronary artery disease (CAD) to evaluate platelet aggregation in blood samples withdrawn simultaneously from the aorta and coronary sinus. At rest, mean platelet aggregation in coronary venous blood was significantly lower than that in aortic blood. Platelet counts in coronary venous blood were also lower than in the aortic blood in each of the six CAD patients in whom counts were done. Platelet aggregation was lower in seven patients who were taking propranolol than in the remaining nine who were not taking propranolol. During tachycardia stress, platelet aggregation increased in all patients, but the magnitude of increase was greater in patients not taking propranolol. In four other patients without CAD, platelet aggregation and counts were also studied in the same fashion and were similar in both the aortic and coronary venous blood. These data suggest that in certain CAD patients, platelet consumption or destruction within atherosclerotic vasculature may occur. Propranolol may reduce platelet aggregation at rest and modify excessive aggregation during tachycardia stress in certain CAD patients.
我们研究了16例冠状动脉疾病（CAD）患者，以评估同时从主动脉和冠状窦采集的血样中的血小板聚集情况。静息时，冠状静脉血中的平均血小板聚集显著低于主动脉血中的平均血小板聚集。在进行计数的6例CAD患者中，冠状静脉血中的血小板计数也低于主动脉血中的血小板计数。服用普萘洛尔的7例患者的血小板聚集低于其余9例未服用普萘洛尔的患者。在心动过速应激期间，所有患者的血小板聚集均增加，但未服用普萘洛尔的患者增加幅度更大。在另外4例无CAD的患者中，也以同样的方式研究了血小板聚集和计数，主动脉血和冠状静脉血中的情况相似。这些数据表明，在某些CAD患者中，动脉粥样硬化血管内可能发生血小板消耗或破坏。普萘洛尔可能会降低某些CAD患者静息时的血小板聚集，并改变心动过速应激期间的过度聚集。
