Mehta J, Mehta P, Pepine C J
Clin Cardiol. 1978 Aug;1(2):96-100. doi: 10.1002/clc.4960010208.
Platelet aggregation was studied in aortic and coronary sinus blood samples obtained from 18 patients with coronary artery disease (CAD). Using epinephrine and ADP as aggregating agents, platelet aggregation was lower in coronary venous blood than in aortic blood. In nine patients on long-term propranolol therapy, platelet aggregation was lower in both aortic and coronary venous blood compared to the nine patients not taking propranolol. Four other subjects without angiographic evidence of coronary disease exhibited no difference in platelet aggregation in aortic and coronary sinus blood. These data suggest that platelet aggregation is lower in the coronary venous blood of certain patients with coronary disease and chronic propranolol treatment may reduce aggregation in both aortic and coronary sinus blood.
对18例冠心病（CAD）患者采集的主动脉血和冠状窦血样本进行了血小板聚集研究。以肾上腺素和二磷酸腺苷（ADP）作为聚集剂，冠状静脉血中的血小板聚集低于主动脉血。在9例接受长期普萘洛尔治疗的患者中，与9例未服用普萘洛尔的患者相比，主动脉血和冠状静脉血中的血小板聚集均较低。另外4例无冠状动脉造影证据的受试者，其主动脉血和冠状窦血中的血小板聚集无差异。这些数据表明，某些冠心病患者的冠状静脉血中血小板聚集较低，长期普萘洛尔治疗可能会降低主动脉血和冠状窦血中的聚集。
