Mehta J, Mehta P, Burger C, Pepine C J
Atherosclerosis. 1978 Oct;31(2):169-75. doi: 10.1016/0021-9150(78)90162-4.
We evaluated platelet aggregation in vitro in blood samples drawn simultaneously from aorta and coronary sinus. Platelet aggregation was significantly lower in the coronary venous blood than in the aortic blood in patients with coronary artery disease. Lower platelet counts were also observed in coronary venous blood. No such differences were seen in subjects with normal coronary arteries. Oral administration of aspirin eliminated the differences in platelet aggregation and counts across the myocardial vascular bed. These observations suggest that platelet sequestration in the myocardial vasculature may be related to the presence of disease in the coronary arteries.
我们在同时从主动脉和冠状静脉窦采集的血液样本中对血小板聚集进行了体外评估。在冠状动脉疾病患者中，冠状静脉血中的血小板聚集显著低于主动脉血中的血小板聚集。在冠状静脉血中还观察到较低的血小板计数。在冠状动脉正常的受试者中未观察到此类差异。口服阿司匹林消除了心肌血管床中血小板聚集和计数的差异。这些观察结果表明，心肌血管系统中血小板的滞留可能与冠状动脉疾病的存在有关。
