Fuller R W
Annu Rev Pharmacol Toxicol. 1980;20:111-27. doi: 10.1146/annurev.pa.20.040180.000551.
Drugs with improved potency and specificity are becoming available for the pharmacologic manipulation of serotonin neurons in brain. Both enhancement and impairment of serotoninergic function can now be achieved by drugs acting through different mechanisms. Drugs of this sort are not only valuable tools for exploring functional roles of serotonin neurons but they have real or potential value in the treatment of diseases like mental depression, obesity, myoclonus or other movement disorders, pain, hypertension, and endocrine dysfunction.
效力和特异性得到提高的药物正可用于对大脑中血清素神经元进行药理学调控。现在，通过不同机制起作用的药物既能增强也能损害血清素能功能。这类药物不仅是探索血清素神经元功能作用的宝贵工具，而且在治疗诸如精神抑郁症、肥胖症、肌阵挛或其他运动障碍、疼痛、高血压和内分泌功能障碍等疾病方面具有实际或潜在价值。
