Candy D C, Larcher V F, Tripp J H, Harries J T, Harvey B A, Soothill J F
Arch Dis Child. 1980 Mar;55(3):189-93. doi: 10.1136/adc.55.3.189.
Four patients with defective yeast opsonisation and protracted diarrhoea are reported. Plasma infusions improved the opsonising function in all 4 and the diarrhoea in 3. This immunological abnormality was assessed in 100 sequential patients with chronic diarrhoea associated with various gastrointestinal disorders; 52 with protracted diarrhoea and failure to thrive of undetermined cause, 26 with 'toddler diarrhoea', 8 with coeliac disease, 5 with chronic inflammatory bowel disease, and 9 with miscellaneous disorders. 23% of the patients with protracted diarrhoea of undetermined cause had defective opsonisation, a greater proportion (P less than 0.05) than that in 'toddler diarrhoea' or the remaining patients, in whom the frequency (4%) was similar to that (5%) in healthy populations. We suggest that yeast opsonisation be tested in children with protracted diarrhoea, as plasma infusions can be an effective form of treatment.
报告了4例酵母调理作用缺陷且腹泻迁延不愈的患者。血浆输注改善了所有4例患者的调理功能，其中3例的腹泻症状也得到改善。对100例因各种胃肠道疾病导致慢性腹泻的连续患者进行了这种免疫异常评估；52例腹泻迁延不愈且病因不明、发育不良，26例患有“幼儿腹泻”，8例患有乳糜泻，5例患有慢性炎症性肠病，9例患有其他杂症。病因不明的迁延性腹泻患者中有23%存在调理作用缺陷，这一比例高于“幼儿腹泻”患者或其余患者（P<0.05），后两者的频率（4%）与健康人群（5%）相似。我们建议对迁延性腹泻患儿进行酵母调理作用检测，因为血浆输注可能是一种有效的治疗方式。
