三氯乙酸与二甲基亚砜反应在沙门氏菌中产生的短寿命诱变剂。
Short-lived mutagen in Salmonella produced by reaction of trichloroacetic acid and dimethyl sulphoxide.
作者信息
Nestmann E R, Chu I, Kowbel D J, Matula T I
出版信息
Can J Genet Cytol. 1980;22(1):35-40. doi: 10.1139/g80-006.
DOI:10.1139/g80-006
PMID:6992961
Abstract
A chemical reaction occurs when trichloroacetic acid (TCA) is dissolved in dimethyl sulphoxide (DMSO), with the production of a short-lived mutagenic derivative which was detected using the Salmonella/mammalian-microsome plate overlay assay. Other interactions between test chemicals and solvents are discussed. Choice of proper solvents in mutagenicity testing is emphasized.
摘要
当三氯乙酸（TCA）溶解于二甲基亚砜（DMSO）时会发生化学反应，生成一种寿命短暂的诱变衍生物，该衍生物通过沙门氏菌/哺乳动物微粒体平板覆盖试验得以检测。文中还讨论了受试化学物质与溶剂之间的其他相互作用。强调了在致突变性测试中选择合适溶剂的重要性。
Zotero 插件