Fitzgerald P H, McEwan C M, Hamer J W, Beard M E
Cancer. 1980 Jul 1;46(1):135-8. doi: 10.1002/1097-0142(19800701)46:1<135::aid-cncr2820460121>3.0.co;2-n.
A case is presented of a man with Richter's syndrome with diffuse histiocytic lymphoma following a ten-year history of untreated chronic lymphatic leukemia. He did not respond to therapy. The lymphoma cells had 61 chromosomes with aneuploidy of 13 chromosomes and 11 structurally altered chromosomes. Only chromosomes 8, 9, 12, 14, and 18 were diploid and without abnormality. Significantly, part of chromsome 1q was duplicated as in the partial trisomy of 1q reported to characterize a number of hematologic neoplasms. A large marker chromosome with subterminal centromere was a tandem duplication of chromosome 4q.
报告一例患有里氏综合征合并弥漫性组织细胞淋巴瘤的男性患者，其有十年未经治疗的慢性淋巴细胞白血病病史。他对治疗无反应。淋巴瘤细胞有61条染色体，其中13条染色体非整倍体，11条染色体结构改变。仅8号、9号、12号、14号和18号染色体为二倍体且无异常。值得注意的是，1号染色体长臂的一部分发生了重复，如同报道中许多血液系统肿瘤所具有的1号染色体长臂部分三体那样。一条带有亚端粒着丝粒的大标记染色体是4号染色体长臂的串联重复。
