Long J C, Aisenberg A C
Am J Clin Pathol. 1975 Jun;63(6):786-95. doi: 10.1093/ajcp/63.6.786.
Long, John C., AND Aisenberg, Alan C.: Richter's syndrome. A terminal complication of chronic lymphocytic leukemia with distinct clinicopathologic features. Am J Clin Pathol 63: 786-795, 1975. Two patients with chronic lymphocytic leukemia of 8 and 9 years duration had a terminal illness characterized by weight loss, persistent fever, lymphadenopathy, and dysglobulinemia. In both cases autopsy revealed a pleomorphic histiocytic lymphoma which contained multinucleate tumor cells and was associated with persistent chronic lymphocytic leukemia. These two cases are examples of Richter's syndrome, a clinically distinct complication of chronic lymphocytic leukemia that may be confused pathologically with Hodgkin's disease. Review of the medical literature suggests that this syndrome has frequently gone unrecognized. (Key words: Richter's syndrome; Chronic lymphocytic leukemia.)
朗，约翰·C.，以及艾森伯格，艾伦·C.：里氏综合征。慢性淋巴细胞白血病的一种终末期并发症，具有独特的临床病理特征。《美国临床病理学杂志》63: 786 - 795，1975年。两名患有8年和9年慢性淋巴细胞白血病的患者出现了以体重减轻、持续发热、淋巴结病和球蛋白异常血症为特征的终末期疾病。在这两个病例中，尸检均发现了多形性组织细胞淋巴瘤，其中含有多核肿瘤细胞，并与持续性慢性淋巴细胞白血病相关。这两个病例是里氏综合征的实例，这是一种慢性淋巴细胞白血病临床上独特的并发症，在病理上可能与霍奇金病混淆。医学文献回顾表明，这种综合征经常未被识别。（关键词：里氏综合征；慢性淋巴细胞白血病。）
