Skjerven O, Bergan T
Infection. 1979;7 Suppl 4:S398-400. doi: 10.1007/BF01639020.
The effects of a twice daily dosage of a combination of 410 mg sulphadiazine + 90 mg trimethoprim (SD + TMP) and 800 mg sulphamethoxazole + 160 mg trimethoprim (SMZ + TMP) were compared in uncomplicated urinary tract infections. All but one patient in each treatment group, i.e. 36 SD + TMP treated and 42 SMZ + TMP treated patients respectively, were cured. The percentage of side-effects related to therapy in the patients receiving the combination with sulphadiazine was 15.1% and in those with sulphamethoxazole 23.7%. Due to the small number tested, however, differences were not statistically different. It is noteworthy that only one of the SD + TMP patients had to stop therapy because of a rash, whereas therapy was stopped for this reason in three of the SMZ + TMP patients. SD + TMP represents a good alternative to SMZ + TMP in the treatment of urinary tract infections.
在单纯性尿路感染中，比较了每日两次服用410毫克磺胺嘧啶+90毫克甲氧苄啶（SD + TMP）和800毫克磺胺甲恶唑+160毫克甲氧苄啶（SMZ + TMP）组合的效果。每个治疗组除一名患者外，即分别有36名接受SD + TMP治疗的患者和42名接受SMZ + TMP治疗的患者均治愈。接受磺胺嘧啶组合治疗的患者中与治疗相关的副作用百分比为15.1%，接受磺胺甲恶唑治疗的患者中为23.7%。然而，由于测试数量较少，差异无统计学意义。值得注意的是，SD + TMP组中只有一名患者因皮疹不得不停止治疗，而SMZ + TMP组中有三名患者因此原因停止治疗。在尿路感染的治疗中，SD + TMP是SMZ + TMP的一个良好替代方案。
