Hollingsworth J W, Dunne J V, Small D, Rose J E, Vaughan J H
Int Arch Allergy Appl Immunol. 1980;62(3):302-8. doi: 10.1159/000232526.
We have encountered two types of variability in the numbers of cells making antibodies in vitro to sheep erythrocytes (PFC) in pokeweed-stimulated human peripheral blood mononuclear lymphocytes (PBM). One is a variation in number of PFC generated by the PBM of one individual compared -o that of another, which is probably an in vitro counterpart to the well known individual variation in in vivo antibody responsiveness and presumed to be T cell controlled. The other variability is in numbers of PFC found in replicate tubes from a given individual. This variation is not T cell controlled, but rather is releated to the relative number of monocytes in the system. Enhancement by monocytes of the numbers of PFC generated is also demonstrated.
我们在体外培养的由商陆刺激的人外周血单个核细胞（PBM）产生抗绵羊红细胞抗体的细胞（PFC）数量中遇到了两种变异性。一种是一个个体的PBM产生的PFC数量与另一个个体的相比存在差异，这可能是体内抗体反应性中众所周知的个体差异在体外的对应情况，并且推测是由T细胞控制的。另一种变异性是在来自给定个体的重复试管中发现的PFC数量的变化。这种变化不是由T细胞控制的，而是与系统中单核细胞的相对数量有关。单核细胞对产生的PFC数量的增强作用也得到了证实。
