人淋巴细胞在体外的抗体反应。噬斑形成细胞前体的特异性和物理特性。

Antibody responses of human lymphocytes in vitro. Specificity and physical properties of plaque-forming cell precursors.

作者信息

Finlay G J, Booth R J, Marbrook J

出版信息

Aust J Exp Biol Med Sci. 1979 Dec;57(6):587-96. doi: 10.1038/icb.1979.62.

DOI:10.1038/icb.1979.62

Abstract

When human tonsillar lymphocytes are cultured with pokeweed mitogen they generate a larger number of antibody-secreting cells. A substantial number of the plaque-forming cells generated have specificity for sheep erythrocytes but very few are specific for either bovine or horse erythrocytes. We have investigated the physical properties of sheep erythrocyte-specific precursors and have found that they have the characteristics of larger lymphocytes and are heterogeneous with respect to density. Our results support the concept that the percursors which can be induced by pokeweed mitogen to develop into plaque-forming cells belong to a pre-activated sub-population of lymphocytes.

摘要

当用人扁桃体淋巴细胞与商陆有丝分裂原一起培养时，它们会产生大量抗体分泌细胞。所产生的大量噬斑形成细胞对绵羊红细胞具有特异性，但对牛或马红细胞具有特异性的细胞却很少。我们研究了绵羊红细胞特异性前体细胞的物理特性，发现它们具有较大淋巴细胞的特征，并且在密度方面具有异质性。我们的结果支持这样的概念，即可以被商陆有丝分裂原诱导发育成噬斑形成细胞的前体细胞属于淋巴细胞的预激活亚群。