含咪唑抗真菌药物对白色念珠菌中甾醇生物合成的抑制作用。
Inhibition of sterol biosynthesis in Candida albicans by imidazole-containing antifungals.
作者信息
Marriott M S
出版信息
J Gen Microbiol. 1980 Mar;117(1):253-5. doi: 10.1099/00221287-117-1-253.
PMID:6993625
Abstract
A simple procedure for studying sterol biosynthesis in cell-free homogenates of Candida albicans is described. The activities of some imidazole-containing antifungals (tioconazole, clotrimazole, econazole, ketoconazole and miconazole) as inhibitors of sterol C-14 demethylation have been determined using this technique.
摘要
描述了一种用于研究白色念珠菌无细胞匀浆中甾醇生物合成的简单程序。使用该技术测定了一些含咪唑抗真菌剂（噻康唑、克霉唑、益康唑、酮康唑和咪康唑）作为甾醇C-14去甲基化抑制剂的活性。
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