胍法辛对原发性高血压和肾性高血压的急慢性肾脏影响。
Acute and chronic renal effects of guanfacine in essential and renal hypertension.
作者信息
Roeckel A, Heidland A
出版信息
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):141S-149S. doi: 10.1111/j.1365-2125.1980.tb04922.x.
Abstract
- Antihypertensive drugs may influence renal function, due to haemodynamic effects and altered release of hormones. 2. Acute and chronic renal effects (glomerular filtration rate (GFR) renal plasma flow (CPAH); diuresis; electrolyte clearances (CNa+, CK+, CCa++, CPO4 3-) of guanfacine have been investigated. 3. Acute intravenous injection induced a marked decrease in GFR, renal blood flow, diuresis and electrolyte clearances. These effects were less pronounced after oral administration. 4. In long-term antihypertensive treatment these effects are less prominent. 5. EFfects of guanfacine on blood pressure and heart rate are similar to those of clonidine (initial pressor response and bradycardia after intravenous injection).
摘要
- 抗高血压药物可能会影响肾功能，这是由于血流动力学效应和激素释放改变所致。2. 已经研究了胍法辛的急性和慢性肾脏效应（肾小球滤过率（GFR）、肾血浆流量（CPAH）；利尿；电解质清除率（CNa+、CK+、CCa++、CPO4 3-））。3. 急性静脉注射导致GFR、肾血流量、利尿和电解质清除率显著下降。口服给药后这些效应不太明显。4. 在长期抗高血压治疗中，这些效应不太突出。5. 胍法辛对血压和心率的影响与可乐定相似（静脉注射后的初始升压反应和心动过缓）。
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