Korenman S G
Cancer. 1980 Aug 15;46(4 Suppl):874-8. doi: 10.1002/1097-0142(19800815)46:4+<874::aid-cncr2820461305>3.0.co;2-#.
Endocrine studies relating to breast cancer are reviewed and the conclusion is reached that studies of hormone levels and hormone excretion to date are inconsistent and inadequate to explain the epidemiologic characteristics of the disease. A new paradigm termed the "estrogen window hypothesis" is introduced. Breast cancer risk is related to the duration of unopposed estrogen exposure during puberty and the early postmenarchial period and during the perimenopausal period. These two estrogen windows provide periods of maximum inducibility by environmental carcinogens. The hypothesis is supported by studies of the survivors of the atomic bomb blasts in Hiroshima and Nagasaki and of women having repeated fluoroscopy for management of tuberculosis. The hypothesis generates many testable conclusions. If verified, the hypothesis could lead to significant public health initiatives.
对与乳腺癌相关的内分泌研究进行了综述，得出的结论是，迄今为止关于激素水平和激素排泄的研究并不一致，也不足以解释该疾病的流行病学特征。引入了一种新的范式，称为“雌激素窗口假说”。乳腺癌风险与青春期、初潮后早期以及围绝经期无对抗雌激素暴露的持续时间有关。这两个雌激素窗口为环境致癌物提供了最大诱导期。广岛和长崎原子弹爆炸幸存者以及因结核病管理而多次接受荧光透视检查的女性的研究支持了这一假说。该假说产生了许多可检验的结论。如果得到证实，这一假说可能会引发重大的公共卫生举措。
