Sartwell P E, Arthes F G, Tonascia J A
J Natl Cancer Inst. 1977 Dec;59(6):1589-92. doi: 10.1093/jnci/59.6.1589.
We studied 284 patients (20-74 years of age) with carcinoma of the breast and 367 controls; all were admitted to one hospital between 1969 and 1972. The disease was associated with nulliparity, first pregnancy over 20 years of age, premenopausal status, and a lower frequency of artificial menopause. After adjustment for these factors, no significant difference was found between the breast cancer patients and controls in their prior use of either estrogens or oral contraceptives, but the confidence limits on the relative risk, especially for oral contraceptives, were large.
我们研究了284例年龄在20至74岁之间的乳腺癌患者以及367名对照者；所有患者及对照者均于1969年至1972年间入住同一家医院。该疾病与未生育、首次怀孕年龄超过20岁、绝经前状态以及较低的人工绝经频率有关。在对这些因素进行调整后，乳腺癌患者与对照者在既往使用雌激素或口服避孕药方面未发现显著差异，但相对风险的置信区间较大，尤其是口服避孕药方面。
