Cohen H N, Beastall G H, Fyffe J A, Fitzgerald V, Thomson J A
Clin Endocrinol (Oxf). 1980 Aug;13(2):207-11. doi: 10.1111/j.1365-2265.1980.tb01043.x.
The growth hormone (GH) and prolactin (PRL) responses following administration of 10 mg i.v. metoclopramide (MCP) ('Maxolon'--Beecham Pharmaceuticals) have been examined in thirty adolescent males with short stature and delayed puberty, either of whom have isolated growth hormone deficiency. The results demonstrate that peak GH and PRL levels following stimulation were highly significantly correlated when all subjects were analysed together (r = 0.61, P < 0.001) but when the responses of the GH deficient and non-deficient groups of subjects were analysed separately no significant correlation was obtained (P > 0.1), this reflected the fact that the PRL response to MCP was significantly lower in the GH deficient group (P < 0.0002). In addition two boys who demonstrated biochemical GH deficiency prior to puberty only, showed PRL responses similar to boys with normal GH reserves. The results suggest that the PRL response to MCP may be of value in the assessment of stimulation tests of GH reserve, as well as in the selection of patients for treatment with GH.
对30名身材矮小且青春期延迟的青少年男性进行了研究，这些男性均患有孤立性生长激素缺乏症，静脉注射10毫克甲氧氯普胺（MCP，“灭吐灵”——比彻姆制药公司生产）后，检测其生长激素（GH）和催乳素（PRL）的反应。结果表明，当对所有受试者进行综合分析时，刺激后的GH峰值和PRL水平高度显著相关（r = 0.61，P < 0.001），但当分别分析生长激素缺乏组和非缺乏组受试者的反应时，未发现显著相关性（P > 0.1），这反映出在生长激素缺乏组中，PRL对MCP的反应显著更低（P < 0.0002）。此外，有两名男孩仅在青春期前表现出生化性生长激素缺乏，其PRL反应与生长激素储备正常的男孩相似。结果表明，PRL对MCP的反应可能在评估生长激素储备刺激试验以及选择生长激素治疗患者方面具有价值。
