Chen Y
Immunol Commun. 1980;9(3):260-76.
The effect of thyroxine on the immune response of BALB/c mice to sheep erythrocytes was investigated. In mice rendered hyperthyroid by subcutaneous injections of T4 the primary immune response to an injection of SRBC in vivo did not show a consistent increase in splenic anti-SRBC plaque-forming cells. However, the total number of splenic cells in T4-treated mice was generally decreased, and thus, the number of PFC per 10(6) splenic cells in T4-treated mice was higher than those of saline and buffer controls. In in-vitro primary response to SRBC PFC per culture (3x10(7) splenic cells) increased significantly in T4-injected animals as compared with controls. The calculated PFC per spleen also increased significantly. The addition of T4 to normal splenic cell cultures enhanced the primary immune response to SRBC in vitro. The optimum concentration of T4 was found to be 10(-8) M. These results indicate a direct enhancing effect of T4 on the immune response of lymphoid cells. This enhancing effect, however, may be attenuated in vivo by the alteration of the number and/or composition of lymphoid cells brought about directly or indirectly by injections of exogenous thyroxine.
研究了甲状腺素对BALB/c小鼠针对绵羊红细胞的免疫反应的影响。在通过皮下注射T4而导致甲状腺功能亢进的小鼠中，对体内注射SRBC的初次免疫反应并未显示出脾抗SRBC斑块形成细胞持续增加。然而，T4处理组小鼠的脾细胞总数通常减少，因此，T4处理组小鼠每10(6)个脾细胞中PFC的数量高于生理盐水和缓冲液对照组。在对SRBC的体外初次反应中，与对照组相比，T4注射动物中每个培养物（3x10(7)个脾细胞）的PFC显著增加。计算得出的每个脾脏的PFC也显著增加。向正常脾细胞培养物中添加T4可增强体外对SRBC的初次免疫反应。发现T4的最佳浓度为10(-8)M。这些结果表明T4对淋巴细胞的免疫反应具有直接增强作用。然而，这种增强作用在体内可能会因外源性甲状腺素注射直接或间接导致的淋巴细胞数量和/或组成的改变而减弱。
