Stepanova Natalia
State Institution "Institute of Nephrology National Academy of Medical Science of Ukraine", Kyiv, Ukraine.
Front Pharmacol. 2022 Mar 10;13:780122. doi: 10.3389/fphar.2022.780122. eCollection 2022.
A comprehensive understanding of urinary tract infections (UTIs), one of the most common human infections, is required as they are complex and poorly understood diseases. Periurethral and vaginal colonization by rectal flora, with the constant presence of pathogens in the urethra, is the initial step of the recurrent UTIs pathway. Current scientific data describe the genetic, etiological, biological, and behavioral risk factors for recurring UTIs, but they do not include the effect of intestinal barrier function on the disease. Although gut microbiota has been proposed as the main source for UTIs, the cross-talk between intestinal barrier dysfunction and the recurrence of UTIs has not yet been supported by scientific data. In this opinion review, based on published data and the results of our clinical studies, I aimed to outline the possible contribution of intestinal barrier dysfunction to the pathogenesis of recurrent UTIs. I believe that the unanswered questions raised by this review can guide further experimental and controlled studies to clarify the mechanisms underlying the role of intestinal barrier dysfunction in the pathogenesis of recurrent UTIs.
由于尿路感染（UTIs）是复杂且了解不足的疾病，因此需要对其进行全面了解，它是人类最常见的感染之一。直肠菌群在尿道周围和阴道定植，尿道中持续存在病原体，是复发性尿路感染途径的第一步。目前的科学数据描述了复发性尿路感染的遗传、病因、生物学和行为风险因素，但未包括肠道屏障功能对该疾病的影响。尽管肠道微生物群被认为是尿路感染的主要来源，但肠道屏障功能障碍与复发性尿路感染之间的相互作用尚未得到科学数据的支持。在这篇观点综述中，基于已发表的数据和我们的临床研究结果，我旨在概述肠道屏障功能障碍对复发性尿路感染发病机制的可能作用。我相信，这篇综述提出的未解决问题可以指导进一步的实验和对照研究，以阐明肠道屏障功能障碍在复发性尿路感染发病机制中的作用机制。
