血管活性肽对人体前列环素合成的影响。
Effect of vasoactive peptides on prostacyclin synthesis in man.
作者信息
Barrow S E, Dollery C T, Heavey D J, Hickling N E, Ritter J M, Vial J
出版信息
Br J Pharmacol. 1986 Jan;87(1):243-7. doi: 10.1111/j.1476-5381.1986.tb10177.x.
Abstract
Bradykinin, angiotensin II, arginine vasopressin (AVP) or des-amino-D-arginine vasopressin (DDAVP) were administered by intravenous infusion to 10 healthy men. The concentration of 6-oxo-prostaglandin F1 alpha (6-oxo-PGF1 alpha), the stable hydrolysis product of prostacyclin (PGI2), was measured in plasma using gas chromatography/negative ion chemical ionisation mass spectrometry. Dose-related increases in plasma concentrations of 6-oxo-PGF1 alpha occurred during administration of bradykinin (100-3200 ng kg-1 min-1). The concentrations of 6-oxo-PGF1 alpha rose from baseline values in the range less than 1.0-4.9 pg ml-1 to 24.9-47.6 pg ml-1 at maximum tolerated infusion rates. There were no changes in the concentrations of 6-oxo-PGF1 alpha during administration of angiotensin II, AVP or DDAVP at infusion rates which caused haemodynamic changes.
摘要
对10名健康男性静脉输注缓激肽、血管紧张素II、精氨酸加压素（AVP）或去氨基-D-精氨酸加压素（DDAVP）。使用气相色谱/负离子化学电离质谱法测定血浆中前列环素（PGI2）的稳定水解产物6-氧代-前列腺素F1α（6-氧代-PGF1α）的浓度。在输注缓激肽（100 - 3200 ng kg-1 min-1）期间，血浆6-氧代-PGF1α浓度出现剂量相关的增加。在最大耐受输注速率下，6-氧代-PGF1α的浓度从基线值（范围小于1.0 - 4.9 pg ml-1）升至24.9 - 47.6 pg ml-1。在引起血流动力学变化的输注速率下，输注血管紧张素II、AVP或DDAVP期间，6-氧代-PGF1α的浓度没有变化。
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