Lycheva T A, Khitrovo I A, Kosoĭ G Kh, Khesina A Ia, Belitskiĭ G A
Eksp Onkol. 1990;12(2):17-20.
Genotoxicity of tar samples collected at the Kemerovo and Altai by-product coke plants has been studied, the contribution of benz(a)pyrene (BP) into the total mutagenic activity of extracts being estimated. Both direct and indirect mutagenicity of the samples is determined in the Ames test. A direct mutagenic effect of coal tar may be attributed neither to the BP action nor to other polycyclic aromatic hydrocarbons. The onset of the His revertant induction in Salmonella typhimurium strains Ta 100 and TA 97 treated with the coal tar activated by the S-9 mixture is observed in doses containing BP an order lower than threshold of its activity found in sole experiment. The highest mutagenic effect of the activated coal tar is observed at a dose containing the minimal active sole dose of BP (0.72-1.12 micrograms per plate).
对克麦罗沃和阿尔泰副产品焦化厂采集的焦油样品的遗传毒性进行了研究，评估了苯并(a)芘（BP）对提取物总诱变活性的贡献。通过艾姆斯试验测定了样品的直接和间接诱变性。煤焦油的直接诱变作用既不能归因于BP的作用，也不能归因于其他多环芳烃。在用S-9混合物活化的煤焦油处理的鼠伤寒沙门氏菌菌株Ta 100和TA 97中，His回复突变体诱导的起始剂量所含的BP比单独实验中发现的其活性阈值低一个数量级。活化煤焦油的最高诱变效应出现在含有BP最小活性单独剂量（每平板0.72 - 1.12微克）的剂量下。
