Clark S A, Stumpf W E, Sar M, DeLuca H F, Tanaka Y
Cell Tissue Res. 1980;209(3):515-20. doi: 10.1007/BF00234764.
Mature rats raised on a vitamin D deficient diet were injected with tritium labeled, 1,25 dihydroxyvitamin D3. Concentration of radioactivity, which is prevented by pretreatment with unlabeled 1,25 dihydroxyvitamin D3, is found in nuclei of cells that are centrally located in pancreatic islets. The central location of these cells and supportive evidence from the literature suggest that they are B-cells, and that 1,25 dihydroxyvitamin D3 has a direct and genomic action on B-cell functions including insulin secretion.
用缺乏维生素D的饮食饲养的成年大鼠被注射了氚标记的1,25 - 二羟基维生素D3。放射性的浓度在胰岛中央位置的细胞核中被发现，而未标记的1,25 - 二羟基维生素D3预处理可阻止这种放射性浓度的出现。这些细胞的中央位置以及文献中的支持性证据表明它们是B细胞，并且1,25 - 二羟基维生素D3对包括胰岛素分泌在内的B细胞功能具有直接的基因组作用。
