氯巴占单剂量每日一次治疗焦虑症：与地西泮常规多剂量治疗的双盲对照研究

Single daily dose treatment of anxiety with clobazam: a double-blind study versus normal multiple-dose treatment with diazepam.

作者信息

Botter P A

出版信息

Curr Med Res Opin. 1980;6(9):593-7. doi: 10.1185/03007998009109494.

Abstract

A double-blind trial was carried out in 45 anxious out-patients to compare the effectiveness and tolerance of clobazam and diazepam. The severity of each patient's symptoms was assessed before, during and at the end of the trial period using the Hamilton Anxiety Rating Scale, and a note kept of any side-effects. The results showed that a single daily dose of 20 mg clobazam was equally as effective as 5 mg diazepam 3-times daily. Clobazam, however, produced considerably fewer side-effects than diazepam, especially drowsiness.

摘要

对45名焦虑症门诊患者进行了一项双盲试验，以比较氯巴占和地西泮的疗效及耐受性。在试验期开始前、期间和结束时，使用汉密尔顿焦虑量表评估每位患者症状的严重程度，并记录任何副作用。结果显示，氯巴占每日单次剂量20毫克与地西泮每日3次、每次5毫克的疗效相当。然而，氯巴占产生的副作用比地西泮少得多，尤其是嗜睡。